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KMID : 1144120180080010117
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Biomedical Engineering Letters
2018 Volume.8 No. 1 p.117 ~ p.125
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A computational model of ureteral peristalsis and an investigation into ureteral reflux
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Hosseini G.
Ji C.
Xu D.
Rezaienia M. A.
Avital E.
Munjiza A.
Williams J. J. R.
Green J. S. A.
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Abstract
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The aim of this study is to create a computational model of the human ureteral system that accurately replicates the peristaltic movement of the ureter for a variety of physiological and pathological functions. The objectives of this research are met using our in-house fluid-structural dynamics code (CgLes?Y code). A realistic peristaltic motion of the ureter is modelled using a novel piecewise linear force model. The urodynamic responses are investigated under two conditions of a healthy and a depressed contraction force. A ureteral pressure during the contraction shows a very good agreement with corresponding clinical data. The results also show a dependency of the wall shear stresses on the contraction velocity and it confirms the presence of a high shear stress at the proximal part of the ureter. Additionally, it is shown that an inefficient lumen contraction can increase the possibility of a continuous reflux during the propagation of peristalsis.
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KEYWORD
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CFD, Ureter, Reflux, PUJ, VUJ, VUR
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